Synaptic Zn2+and febrile seizure susceptibility
نویسندگان
چکیده
منابع مشابه
Identification of Srp9 as a febrile seizure susceptibility gene
OBJECTIVE Febrile seizures (FS) are the most common seizure type in young children. Complex FS are a risk factor for mesial temporal lobe epilepsy (mTLE). To identify new FS susceptibility genes we used a forward genetic strategy in mice and subsequently analyzed candidate genes in humans. METHODS We mapped a quantitative trait locus (QTL1) for hyperthermia-induced FS on mouse chromosome 1, c...
متن کاملIntergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgen...
متن کاملAfebrile seizure subsequent to initial febrile seizure.
INTRODUCTION Febrile seizure (FS) is the most common paediatric neurological problem. The purpose of this study was to determine the frequency of afebrile seizures subsequent to FS in children with initial FS and to evaluate its risk factors. METHODS A prospective study was conducted on all children (age 6 months to 6 years) referred with initial FS to the Shahid Sadoughi Hospital, Yazd, Iran...
متن کاملCorrigendum to “Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures” (EBioMedicine 17 (2017) 206–215)
Dengchang Wu , Bo Feng , Yunjian Dai , Xiaohua Wu , Bin Chen , Cenglin Xu , Yangshun Tang , Kang Wang , Shihong Zhang , ShuangWang , Benyan Luo , Zhong Chen a,c,⁎ a Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China b Department of Neurology, Collaborative Innovati...
متن کاملVariations in inflammation-related genes may be associated with childhood febrile seizure susceptibility
PURPOSE To investigate whether genetic variants in inflammation-related genes are associated with increased risk of childhood-onset febrile seizures. METHOD Tagging single nucleotide polymorphisms (SNPs) from 19 inflammation-related candidate genes were identified and genotyped on the Sequenom platform in a sample of Caucasian childhood-onset febrile seizures cases (n=98) compared to ethnicit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2016
ISSN: 0007-1188
DOI: 10.1111/bph.13658